PP122 Prognostic value of IMP3 and SLUG immunohistochemistry in breast carcinoma

Breast cancer is the most common worldwide. Tumor metastasis cause of death in breast cancer. In view high mortality patients, there a need to identify new prognostic biomarkers. IMP3 has role induction Epithelial-Mesenchymal Transition (EMT) and SLUG an EMT marker. Both these have been implicated metastasis. Hence, might prove be potential therapeutic targets future. This was retrospective study conducted on 60 carcinoma cases tertiary care center North India using tissue microarrays. Demographic clinicopathological details were recorded. Immunohistochemistry for performed. Their IHC expression evaluated terms percentage cell-positivity semi-quantitatively intensity staining (weak= 1, moderate= 2 strong= 3). Data recorded pre-designed proforma analyzed. positivity found 87% 90% cases. significantly associated with tumor size (p = 0.03) TNM stage 0.024). showed significant association histological grade 0.009), 0.036) molecular subtype 0.03). immunoexpression 0.006) its age 0.025) 0.004). A highly <0.001) between intensities <0.001). Significant correlation also cell positivities proves them poor markers. Also, positive highlights their proposed invasiveness aggressiveness via carcinomas. SLUG-based targeted therapies useful treatment carcinoma.